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Mutaţii la nivelul genei APC cauza atât polipoză clasic şi atenuate adenomatoasă familială. Mutations in the APC gene cause both classic and attenuated familial adenomatous polyposis. Tumorile desmoide pot apărea la persoanele care au antecedente de polipoză coli, un sindrom ereditar de cancer de colon. Desmoid tumors may occur in individuals who have a history of polyposis coli, a hereditary colon cancer syndrome.

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